COVID-19 - Antigen rapid Tests

COVID-19 - Antigen rapid Tests


Although the RT-qPCR technique is the official technique for the diagnosis of COVID-19, there are other methods available such as serological tests, rapid salivary tests and antigenic tests.
Antigenic tests are the most recent tests developed for the diagnosis of COVID-19. They are rapid tests designed to detect antigens of the SARS-CoV-2 virus, i.e. proteins present on the surface of the virus. The test is performed on a nasopharyngeal swab specimen as in the RT-qPCR tests. However, although the sensitivity of antigenic tests is lower than for RT-qPCR tests, they have the advantage of being faster (15-30 minutes) and less expensive. In addition, like serological tests, they do not require any special equipment.
Antigen rapid tests are based on the principle of immuno-chromatography as are serological tests. Antibodies directed against the SARS-Cov-2 virus antigens (usually the nucleocapsid protein or N protein) will detect the virus in the nasopharyngeal sample. A positive result with an antigen test will need to be confirmed by an RT-qPCR test.

Sensitivity
94.55%
98.55%
92%
96.4%
95.9%
Specificity
100%
100%
99.26%
99.2%
99.9%
Clinical study
216 patients
285 patients
210 patients
204 patients
273 patients
Validated samples
NP and OP
NP and OP
Nasal
NP
NP, OP and salive
Country of origin
Canada
China
China
China
China
Included swabs
Yes
Yes
Yes
Yes
Yes (NP+Salive)

NP = Nasopharyngeal
OP = Oropharyngeal

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